Spread pizza sauce on one tortilla, leaving a border for the crust. Sprinkle with half the shredded mozzarella cheese and cheddar cheese. For convenience, you can assemble everything in the air fryer basket.
Place a second tortilla on top, and repeat with the remaining sauce, cheese, pepperoni or ham, and other desired toppings.
Air fry for 4-5 minutes at 375°F (190°C) until cheese is melted and bubbly and the crust is crispy. Check doneness at 4 minutes.